Biological systems are incredibly complex, even classical 'textbook' pathways are much more detailed than they appear. Our lab seeks to understand this complexity.
There is considerable benefit to be made when scientific disciplines meet, therefore we apply physical methods to study biological systems and use mathematical models to understand our results.
We specialise in using a single molecule reductionist approach to pull apart and then rebuild complex molecular machineries.
A number of diseases are linked to alterations in physical parameters of molecules and we aim to understand disease at this level.
Neil Kad (PI)
Single Molecule Biophysics
Alessio Inchingolo (BHF PhD Student)
Thin filament biophysics
Talking a lot
Luke Springall (Kent PhD Student)
NER dynamics and protein complex assembly
Jamie Barnett (BBSRC iCASE PhD Student)
Dark-field imaging of rapid events on DNA tightropes
Not running marathons
Rob Charman (PhD student)
Gibson assembly and studying amyloid
Looking like Jamie
Alex Moores (BBSRC Postdoc)
Microbiology, genome engineering
Sliding backwards down hills
Jingyu Wang (Now at the University of Oxford)
Nicola Don (Now running a business)
Harish Cheruvara (Now at Scripps)
Michelle Simons (Now at the University of Essex)
Svetlana Gretton (Now at the University of Essex)
Rama Desai (Formerly at Imperial College, now running a business)
Craig Hughes (Now at the University of Cambridge)
Stavros Azinas (Now a CIC bioGUNE, Spain)
Cassidy Mackenzie (Now at the University of Kent)
Amna Allafi (Now at the University of Essex)
Merle Nazareth (Now working for the NHS)
Daniel Croucher (Field Applications Specialist for Photometrics)
Why study single molecules?
We study complex molecular systems one molecule at a time because we don't want the noise created by studying 1017 molecules studied in a typical bulk phase experiment.
"Imagine a room full of people saying the same sentence but not all at the same time, all you hear is garbled noise. But using a microphone you could amplify what a single person is saying and you'll hear the sentence. This is what we do to investigate complex processes."