• Our system
  • Zhang 2012
  • Optics
  • First SM images
  • Data
  • Return beam in TIRF
  • Single Cells

Biological systems are incredibly complex, even classical 'textbook' pathways are much more detailed than they appear. Our lab seeks to understand this complexity.

There is considerable benefit to be made when scientific disciplines meet, therefore we apply physical methods to study biological systems and use mathematical models to understand our results.

We specialise in using a single molecule reductionist approach to pull apart and then rebuild complex molecular machineries.

A number of diseases are linked to alterations in physical parameters of molecules and we aim to understand disease at this level.

 

Our Group

This email address is being protected from spambots. You need JavaScript enabled to view it. (PI)

Photo

Special skills:

Single Molecule Biophysics

Irritating students

 

This email address is being protected from spambots. You need JavaScript enabled to view it. (BHF PhD Student)

 

 Alessio

Special skills:

Thin filament biophysics

Talking a lot

 

This email address is being protected from spambots. You need JavaScript enabled to view it. (Kent PhD Student)

 

 Luke

 

Special skills:

NER dynamics and protein complex assembly

Looking good

 

This email address is being protected from spambots. You need JavaScript enabled to view it. (BBSRC iCASE PhD Student)

 

 Jamie

 Special skills:

Dark-field imaging of rapid events on DNA tightropes

Not running marathons

 

This email address is being protected from spambots. You need JavaScript enabled to view it. (PhD student)

Rob C

Special skills:

Gibson assembly and studying amyloid

Looking like Jamie

 

This email address is being protected from spambots. You need JavaScript enabled to view it. (BBSRC Postdoc)

Alex photo

Special skills:

Microbiology, genome engineering

Sliding backwards down hills

 

 

Former members

Jingyu Wang (Now at the University of Oxford)

Nicola Don (Now running a business)

Harish Cheruvara (Now at Scripps)

Michelle Simons (Now at the University of Essex)

Svetlana Gretton (Now at the University of Essex)

Rama Desai (Formerly at Imperial College, now running a business)

Craig Hughes (Now at the University of Cambridge)

Stavros Azinas (Now a CIC bioGUNE, Spain)

Cassidy Mackenzie (Now at the University of Kent)

Amna Allafi (Now at the University of Essex)

Merle Nazareth (Now working for the NHS)

Daniel Croucher (Field Applications Specialist for Photometrics)

 

Why study single molecules?

We study complex molecular systems one molecule at a time because we don't want the noise created by studying 1017 molecules studied in a typical bulk phase experiment.

"Imagine a room full of people saying the same sentence but not all at the same time, all you hear is garbled noise. But using a microphone you could amplify what a single person is saying and you'll hear the sentence. This is what we do to investigate complex processes."